Boron flips the script on cyclohexaneConformational analysis of disubstituted cyclohexanes played an outsized role in the development of organic chemistry. It is striking in that context that the comparatively less stable isomers remain challenging to access. Li et al. now report a versatile method to prepare 1,2-ci...

Multicomponent cross-coupling reactions involving alkenes represent a compelling strategy for accessing three-dimensional molecules, a key pursuit in contemporary medicinal chemistry. Transition metal-catalysed processes predominantly necessitate the use of conjugated alkenes or non-activated alkenes equipped with s...

Six-membered rings are ubiquitous structural motifs in bioactive compounds and multifunctional materials. Notably, their thermodynamically disfavoured isomers, like disubstituted cyclohexanes featuring one substituent in an equatorial position and the other in an axial position, often exhibit enhanced physical and b...